The disease beriberi is caused by a nutritional deficiency in vitamin B1 (thiamin). What key mitochondrial enzyme uses thiamin as a coenzyme in a reaction that generates acetyl-CoA, CO2, and NADH + H+ as products; and why is this condition rare in developed countries?
Question 3 options:
Malate dehydrogenase; beriberi is rare because other vitamins can replace thiamin.
Citrate synthase; beriberi is rare because thiamin can be obtained from drinking water.
Pyruvate dehydrogenase; beriberi is rare because many common foods are vitamin-fortified.
Alpha-ketoglutarate dehydrogenase; beriberi is rare because most people eat berries for their oxidants.
Fumarase; beriberi is rare because DNA contains large amounts of thiamin paired with adenine.