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(Solved): 3. In the lecture, we learned that during an action potential Ca2+ concentration at the active zon ...



3. In the lecture, we learned that during an action potential \( \mathrm{Ca}^{2+} \) concentration at the active zone can ris

3. In the lecture, we learned that during an action potential concentration at the active zone can rise one-thousandfold, from to . This has led to the development of all kinds of calcium indicators for optical readout of neuronal activities. You know that the movements of and across the cell membrane constitutes the neuronal action potential. Therefore, you wanted to develop sodium and/or potassium indicators to detect action potentials. Question: Use simple calculations to show if it is feasible to detect intracellular changes of and during an action potential. You may assume the neuron has a shape of sphere with diameter, and the membrane capacitance per unit area is . Assume the resting potential is . The initial concentrations of are , intra-/extra-cellular, being 15 , intra-/extracellular. Assume existing technologies can detect change for for


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To calculate the feasibility of detecting intracellular changes of Na* and K during an action potential, we can use the Nernst equation to determine t
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