(Solved): After Down syndrome, the most common human aneuploidy is the condition known as Klinefelter's syndro ...

After Down syndrome, the most common human aneuploidy is the condition known as Klinefelter's syndrome (XXY). Although individuals with Klinefelter syndrome (47, XXY) undergo X-chromosome inactivation similar to typical XX individuals, they often present symptoms such as reduced testosterone production, infertility, and learning differences. Which of the following best explains why individuals with Klinefelter syndrome still develop a distinct phenotype? X-inactivation falls in indiviluals with more than cee X cleomosome, resulting in trible gene expression from both X clromosomes and the Y cheomosome. Xtructivation in Klinefelter syndrome indiviluals sliences all genes on one X clromosome, but overespression from the Y cleososome leash to the phenotype. The presence of a Y chromosome inderferes with the inscitystion process, causing both X chromosomes to remain active. Some genes on the extra

chromonome escape inactivation, including genes that are also present on the Y chromonome, leading to dosage butalance