(Solved): Correctly arrange the sequence of events in excitation-contraction coupling in cardiac muscle. Rank ...

Correctly arrange the sequence of events in excitation-contraction coupling in cardiac muscle. Rank the options below. Depolarization opens L-type

channels in the T-tubules. A small amount of "rigger"

enters the cytosol, contributing to cell depolarization. That trigger

binds to, and opens, ryanodine

channels in the sarcoplasmic reticulum membrane. Cross-bridge cycling causes force generation and sliding of thick and thin filaments.

-ATPase pumps return

to the sarcoplasmic reticulum and also remove

from the cell, resulting in relaxation. A larger amount of

flows into the cytosol, raising the

concentration. Binding of

to troponin exposes cross-bridge binding sites on thin flaments. The membrane is depolarized by

entry as an action potential begins.