Gout is a disease caused by high levels of uric acid in the blood. The uric acid crystallizes on joints, tendons, and other tissues, leading to swelling and pain. In response to the uric acid crystals, the NLRP3 inflammasome in macrophages becomes activated, leading to inflammation. Which of the following treatments may help to treat the symptoms of gout by specifically targeting the inflammatory processes involved in the disease? anti-IL-4 monoclonal antibodies CTLA-4 Fc fusion protein recombinant IL-1 receptor antagonist sphingosine-1-phosphate receptor agonists