Orlistat (9) is a lipase inhibitor developed by Roche to treat obesity. It was approved by the U.S. Food and Drug Administration in 1999 to be sold under the brand name Alli by GlaxoSmithKline. a) Identify the functional groups and the chiral centers in Orlistat b) A solution of orlistat in pH=10 buffer lost all its lipase inhibitory activity after 20 minutes. Provide a mechanistic explanation for this observation