Phenolics denature proteins and destroy cytoplasmic membranes. remain effective in the presence of detergents or organic material. such as triclosan, have been used widely in various lotions and soaps. reliably inactivate all groups of viruses. denature proteins and destroy cytoplasmic membranes, remain effective in the presence of detergents or organic material, AND phenolics such as triclosan, have been used widely in various lotions and soaps.