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(Solved): Question 2 (0.4 points) Within the active site of a metalloprotease, the interaction of a zincion an ...



Question 2 (0.4 points) Within the active site of a metalloprotease, the interaction of a zincion and a water molecule results in. a large conformational change to the active site, leading to tight substrate binding.

a lower

pK_(a)

of the water molecule, leading to formation of a zinc-hydroxide an active site His residue becoming ionized, leading to its activation as a nucleophile

an altered

K_(M)

value for the protease



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