Question 2 (0.4 points) Within the active site of a metalloprotease, the interaction of a zincion and a water molecule results in. a large conformational change to the active site, leading to tight substrate binding.
◻
a lower
pK_(a)
of the water molecule, leading to formation of a zinc-hydroxide an active site His residue becoming ionized, leading to its activation as a nucleophile
◻
an altered
K_(M)
value for the protease