Read Chapter 14 (antimicrobial drugs) answer following questions: • What is a superinfection and how does one arise? • List five factors to consider when determining the dosage of a drug. • Explain the difference between synergistic and antagonistic drug interactions. • Describe the mode of action of ?-lactams. • Compare and contrast the different types of protein synthesis inhibitors. • Why do inhibitors of bacterial nucleic acid synthesis not target host cells? • How do sulfonamides and trimethoprim selectively target bacteria? • How is disruption of ergosterol biosynthesis an effective mode of action for antifungals? • Why is HIV difficult to treat with antivirals? • List several mechanisms for drug resistance. • How does drug resistance lead to superbugs? • How does one use the information from a Kirby-Bauer assay to predict the therapeutic effectiveness of an antimicrobial drug in a patient? • Compare and contrast MIC and MBC.