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(Solved): This illustration depicts the desk of a medical researcher studying different microbial diseases, T ...
This illustration depicts the desk of a medical researcher studying different microbial diseases, The top folder describes polio, and contains an image of the poliovirus (lower picture) and an image of motor neurons undergoing apoptosis during an active poliovirus infection (top picture). The graph shows the rapid fall of new polio cases per year shortly following the introduction of the polio vaccine. The folder beneath describes malaria, and holds an image of Plasmodium falciparum gliding between red blood cells. Nearby, a bottle of the anti-malaria drug artemisinin, is present. The folder on the right describes tuberculosis, including an image of Mycobacterium tuberculosis, and bottles of the antibiotic rifampicin and the tuberculosis vaccine, BCG (Bacillus Calmette-Guérin). Imagine you open the poliomyelitis folder and begin reading about the disease and pathogen. You encounter the virulence section and see that the organism has a Cl ratio of less than 1. Explain the meaning of this information and how this number is related to the virulence of the poliovirus.
Poliovirus infects human cells by binding to an immunoglobulin-like receptor, CD155 (also known as the poliovirus receptor or PVR) on the cell surface. Interaction of poliovirus and CD155 facilitates an irrever