(Solved): tumors). MCF-7/WT cells do not carry extra copies of the HER2 gene. MCF-7/HER2 cells were engineered ...
tumors). MCF-7/WT cells do not carry extra copies of the HER2 gene. MCF-7/HER2 cells were engineered to carry extra copies of the HER2 gene. Data Table: The percentage of cells undergoing apoptosis (programmed cell death) in cell cultures treated with 4-PR (fenretinide), which induces apoptosis in cancer cells. Question (Spoints): Using the data above on the MCF-7 and MCF-7/HER2 cell lines, provide a prediction about the apoptosis of MDA-MB-453 and BT474 cell lines; explaining the correlation between HER2 expression and the expected response to 4-HPR treatment. Be sure to compare and contrast the data presented for MDA-MB-453 and BT474.