*-You have identified several putative transcription factors (TFs) and would like to determine which major class they belong to—Zinc finger, Leucine Zipper, or basic Helix-Loop-Helix. You can use a molecular prediction tool that shows you the predicted structures of your TFs of interest. How could you examine the structures of your TFs and make a good prediction of their TF family?
*-Integrin expression by cells facilitates adhesion between ECM and between cells.
a)When cells are using integrins to adhere to the ECM, what are the ECM binding partners? For which of these would interfering with RGD domain structures disrupt binding?
b)When cells are using integrins for adherence to another cell, what are the binding partners on the other cells?
c)Explain outside-in vs. inside-out signaling for integrins. In your answer include some information on the conformation of the integrin molecules when they are active vs inactive.