Orlistat and olestra can both lead to undigested lipids in the colon, yet they do so by contrasting mechanisms. Orlistat
q,
whereas olestra
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activates PPAR-gamma; inhibits pancreatic lipase
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inhibits pancreatic lipase; activates PPAR-gamma
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inhibits pancreatic lipase; is a fat substitute that is not a substrate for pancreatic lipase
is a fat substitute that is not a substrate for pancreatic lipase; inhibits pancreatic lipase